Modulation of chemically-induced hepatocarcinogenesis by indole-3-carbinol

mechanisms and species comparison by Aram Oganesian

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Published: Pages: 186 Downloads: 271
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Subjects:

  • Indole.,
  • Cancer -- Immunological aspects.
  • Edition Notes

    Statementby Aram Oganesian.
    The Physical Object
    Pagination186 leaves, bound :
    Number of Pages186
    ID Numbers
    Open LibraryOL18117282M

  Modulation of Chemically-Induced Hepatocarcinogenesis by IndoleCarbinol: Mechanisms and Species Comparison David E. Williams George John Carter: PhD: Binding and Assembly of H5 (and the Globular Domain of H5) onto DNA: Ken Van Holde: Debbie J. Mustacich: PhD   Chemoprevention of chemically-induced mammary carcinogenesis by indolecarbinol. Anticancer Res. ; – Xu M, Orner GA, Bailey GS, Stoner GD, Horio DT, Dashwood RH. Post-initiation effects of chlorophyllin and indolecarbinol in rats given 1,2-dimethylhydrazine or 2-aminomethyl-imidazo[4,5-f]quinoline. Cancer prevention studies of our group have demonstrated that benzyl isothiocyanate (BITC) inhibit methylazoxymethanol (MAM)‐acetate induced intestinal carcinogenesis and diethylnitrosamine (DEN) induced hepatocarcinogenesis in rats, and sinigrin reduced 4‐nitroquinoline 1‐oxide‐induced rat tongue carcinogenesis and DEN‐induced   Effects of indolecarbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)(3-pyridyl)butanone (NNK) and on the metabolism and disposition of NNK in A/J mice. Cancer Res —

Inhibition of proliferation and modulation of estradiol metabolism: novel mechanisms for breast cancer prevention by the phytochemical indolecarbinol. Proceedings of the Society for Experimental Biology and Medicine ,   MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION. Mechanisms of protection against aflatoxin B 1 genotoxicity in rats treated by organosulfur compounds from garlic. Denis Guyonnet, Christine Belloir, Marc Suschetet, Marie-Hélène Siess and Anne-Marie Le Bon,1. Institut National de la Recherche Agronomique, Unité Mixte de Recherche de Toxicologie Alimentaire, BP , 17 rue In another study, the effects of sinigrin and indolecarbinol (I3C) on the hepatocarcinogenesis induced by diethyl-nitrosamine (DEN) were studied in male ACI/N rats. When rats where treated with diethyl-nitrosamine and diet containing ppm. Sinigrin and rats fed with rats where treated with diethyl-nitrosamine and diet containing :// Diallyl sulfide (DAS) and diallyl disulfide (DADS), two garlic constituents, were found previously to inhibit aflatoxin B 1 (AFB 1)-initiated carcinogenesis in rat liver, DADS being the most effective. In order to study the mechanisms involved in this protection, we have examined the ability of liver microsomes and cytosols from DAS- and DADS-treated rats to modulate the mutagenicity and the

The effects of other potential chemopreventive agents, including 5,6‐benzoflavone, butylated hydroxyanisole, indole‐3‐carbinol and phenethylisothiocyanate, on DNA adduct levels in rats have also been shown to correlate with tumorigenicity in the rat mammary gl () [Journal Article] Dietary indolecarbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome Ps in the liver and consequent modulation of estrogen metabolism Cruciferous vegetables benefits. Like most other vegetables, cruciferous vegetables are good sources of a variety of nutrients and phytochemicals that may work synergistically to help prevent cancer 35).One challenge in studying the relationships between cruciferous vegetable intake and cancer risk in humans is separating the benefits of diets that are generally rich in vegetables from those @article{osti_, title = {Identifying Efficacious Approaches to Chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a Mouse Model of Transplacental Carcinogenesis}, author = {Castro, David J and Lohr, Christiane V and Fischer, Kay A and Waters, Katrina M and Webb-Robertson, Bobbie-Jo M and Dashwood, Roderick H and Bailey, George S and Williams, David E

Modulation of chemically-induced hepatocarcinogenesis by indole-3-carbinol by Aram Oganesian Download PDF EPUB FB2

Modulation of diethylnitrosamine-induced hepatocarcinogenesis and ethylguanine formation in rainbow trout by indolecarbinol, B-naphthoflavone, and aroclor Indolecarbinol (I3C) is a naturally occurring component of cruciferous vegetables.I3C has been reported to inhibit tumorigenesis in various target organs, including mammary tissue (Grubbs et al., ), skin (Srivastava and Shukla, ), liver (Oganesian et al., ), endometrium (Kojima et al., ), lung (Chung et al., ), and other target organs (Tanaka et al., ) in various Fong AT, Hendricks JD, Dashwood RH, et al.

Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O 6-ethylguanine formation in rainbow trout by indolecarbinol, α-naphthoflavone, and Aroclor Toxicol Appl Pharmacol.

; –   Supplements IndoleCarbinol (I3C) I3C is available without a prescription as a dietary supplement, alone or in combination ranges between mg/day and mg/day.I3C supplementation increased urinary 2HE 1 concentrations in adults at doses of to mg/day.I3C doses of mg/day or mg/day improved the regression of cervical intraepithelial neoplasia (CIN) ().

Modulation of chemically-induced hepatocarcinogenesis by indolecarbinol: Mechanisms and species comparison. Modulation of flavin-containing monooxygenase in guinea pigs by ascorbic acid and food restriction. Indole 3 carbinol, or I3C, is produced by mastication from glucosinolate, found in high levels in broccoli, kale, cabbage, Brussels sprouts and other cruciferous vegetables, further breaking down in the gut into several active compounds such as diindolylmethane, or DIM, ICZ, NI3C and IAN; Indole 3 carbinol has mounting evidence against environmental toxins, radiation damage, HPV, and colon ,-natural-Tamoxifen.

We completed a phase I trial of indolecarbinol (I3C) in 17 women (1 postmenopausal and 16 premenopausal) from a high-risk breast cancer cohort. After a 4-week placebo run-in period, subjects ingested mg I3C daily for 4 weeks followed by a 4-week period of mg I3C daily.

These chronic doses were tolerated well by all subjects. Hormonal variables were measured near the end of the Indolecarbinol is a potential anti-cancer agent, and it has been found rich in Brassica vegetables.

However, there was few good extraction method of indolecarbinol in cabbage and broccoli. In this work, the wavelength and the ration of mobile phase in determination method, as well as different temperature and pH values in extraction method were all investigated some cultivars of cabbage   3.

Pleiotropic effects of indolecarbinol on multiple signaling targets. Substantial evidence indicates that the antitumor effect of indolecarbinol is attributable to its ability to target a plethora of signaling pathways governing apoptosis, cell cycle progression, hormonal homeostasis, DNA repair, angiogenesis, and multiple drug resistance [reviews: (16–20)].

We have identified a new target for the chemopreventive dietary agent indolecarbinol (I3C) in the antiapoptotic signaling pathway involving phosphatidylinositol 3′-kinase and protein kinase B (PKB)/Akt.

I3C inhibited phosphorylation and activation of PKB in the tumor-derived breast cell line MDA MB, but not in the immortalized breast line HBL Indolecarbinol promotes hepatocarcinogenesis chemically induced carcinogenesis in the rat (53–58) and trout (40), but function as inhibitors in the mouse (6,59,60).

Modulation of diethylnitrosamine-induced hepatocarcinogenesis and ethylguanine formation in rainbow trout by indolecarbinol, B-naphthoflavone, and aroclor (). Modulation of mycotoxin and nitrosamine carcingenesis by indolecarbinol: quantitative analysis of inhibition versus Key Points.

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor of the helix-loop-helix/PAS family. Many compounds interact with the AhR including xenobiotic (“xeno” = foreign) polycyclic aromatic hydrocarbons (PAH) and dioxins, endogenous ligands, Read "Modulation of aflatoxin-B1 hepatocarcinogenesis in trout by dehydroepiandrosterone: initiation/post-initiation and latency effects., Carcinogenesis" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your ://   Title:Molecular Targets, Anti-cancer Properties and Potency of Synthetic Indolecarbinol Derivatives VOLUME: 19 ISSUE: 7 Author(s):Mojgan Noroozi Karimabad, Mehdi Mahmoodi, Abdolah Jafarzadeh, Ali Darekordi, Mohamad Reza Hajizadeh and Gholamhossein Hassanshahi* Affiliation:Molecular Medicine Research Center, Research Institute of Basic Medical Sciences,   We have completed a phase I trial in women of the proposed chemopreventive natural product indolecarbinol (I3C).

Women received oral doses of,1, and 1, mg I3C. Serial plasma samples were analyzed by high-performance liquid chromatography-mass spectrometry for I3C and several of its condensation products.

I3C itself was not detectable in :// Indolecarbinol (I3C) found in various cruciferous vegetables has been shown to exert anti-carcinogenic activity in several target organs.

In this study, we have investigated the effects of I3C on cigarette smoke-related lipophilic DNA adduct formation, potentially a key step in chemical ://   Abstract. The highlighted article in this issue by Tilton et al. (a) is an innovative approach to evaluate the modulation of estrogen receptor (ER) and aryl hydrocarbon (Ah)-receptor pathways as mechanisms underlying indolecarbinol (I3C) tumor promotion in rainbow trout (Onchorhynchus mykiss).I3C and its major in vivo component 3,3′-diindolylmethane (DIM) are potent tumor promoters Abstract.

Indolecarbinol (I3C), a dietary constituent derived from cruciferous vegetables has been shown to exert anti-tumour and chemopreventive activity in vitro and in vivo. 3,3'-diindolylmethane (DIM), an acid condensation product of I3C, exerts promising activity and is thought to be partially responsible for the chemopreventive activity of orally administered :// Modulation of hepatocarcinogenesis by dehydroepiandroster one studied for its anti-obesity properties (38,39), therefore decreased wt gain may be an inappropriate measure of ://   Indolecarbinol is a potential anti-cancer agent, and it has been found rich in Brassica vegetables.

However, there was few good extraction method of indolecarbinol in cabbage and broccoli. In this work, the wavelength and the ration of mobile phase in determination method, as well as different temperature and pH values in extraction method were all investigated some cultivars of cabbage Inhibitory effect of sinigrin and indolecarbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats.

Tanaka T, Mori Y, Morishita Y, Hara A, Ohno T, Kojima T, Mori H. Carcinogenesis, (8) MED: Diindolylmethane is LIKELY SAFE when consumed in the small amounts found in foods.

A typical diet supplies mg of diindolylmethane. It is POSSIBLY SAFE for most people when taken by mouth short-term for medicinal purposes. Taking larger doses of diindolylmethane is POSSIBLY mg of diindolylmethane daily has been reported to lower sodium levels in some  › home › healthy living center › healthy living a-z list.

Abstract. Indolecarbinol (I3C), a major component of cruciferous vegetables 1 is effective as a chemopreventive agent in a number of animal models 2–6 and is being considered for chemoprevention of breast cancer in women 7.

In vivo, in the acidic environment of the stomach, I3C undergoes a series of condensation reactions, resulting in the production of an oligomeric mixture of dimers Modulation ofdiethylnitrosamine-induced hepatocarcinogenesis and ethylguanine formation in rainbow trout by indolecarbinol, ().

Molecu[ar dosimetry ofhepatic aflatoxin Bl-DNA adducts: linear correlation with hepatic cancer risk. Indolecarbinol (I3C) is present in many cruciferous vegetables and is known to possess protective properties against chemically induced toxicity and carcinogenesis.

In the present study, the antimutagenic potential of I3C has been evaluated using in vivo chromosomal aberration (CA) assay as a cytogenetic end ://   Abstract. Indolecarbinol (I3C), a naturally occurring component of broccoli, cabbage, and other members of the family Cruciferae, is a tumor modulator in several animal models that demonstrates significant chemoprevention against development of both spontaneous and chemically induced cancers while conversely eliciting tumor promoter effects in :// Modulation of CYP19 expression by cabbage juices and their active components: indolecarbinol and 3,3′-diindolylmethene in human breast epithelial cell lines.

Gene expression analysis during tumor enhancement by the dietary Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3′-diindolylmethane, in rainbow In conclusion, the ~1% dose of Korean red ginseng has a chemopreventive effect on chemically-induced rat hepatocarcinogenesis by suppression of oxidative stress and modulation of redox-enzymes.

Additionally, more than the 2% dose of KRG may lose the chemopreventive efficacy due to the fact that it cannot improve carcinogen detoxifying   Indolecarbinol (I3C) has shown promising chemopreventive activity against a range of human tumour cell types, but little is known about the effect of this agent on colon cell lines.

Here, we investigated whether inhibition of ODC by I3C could contribute to. Modulation of diethylnitrosamine-induced hepatocarcinogenesis and ethylguanine formation in rainbow trout by indolecarbinol, B-naphthoflavone, and Arochlor Toxicol Appl Pharmacol (). (). Monograph on the evaluation ofcarcinogenic risk of chemicals to man: some organichlorine The safety of IndoleCarbinol supplements during pregnancy and lactation has not been studied.

In addition, it may interfere with a liver enzyme involved in the metabolism of many other therapeutic drugs. There is therefore a potential risk for adverse drug interactions, and caution should be used when IndoleCarbinol is taken with other Indole compounds, obtained from cruciferous vegetables, are well-known for their anti-cancer properties.

In particular, indolecarbinol (I3C) and its dimeric product, 3,3´-diindolylmethane (DIM), have been widely investigated for their effectiveness against a number of human cancers in vitro as well as in vivo.

These compounds are effective inducers of apoptosis and the accumulating